Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome
نویسندگان
چکیده
منابع مشابه
Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome.
Reduced gene dosage of ribosomal protein subunits has been implicated in 5q- myelodysplastic syndrome and Diamond Blackfan anemia, but the cellular and pathophysiologic defects associated with these conditions are enigmatic. Using conditional inactivation of the ribosomal protein S6 gene in laboratory mice, we found that reduced ribosomal protein gene dosage recapitulates cardinal features of t...
متن کاملMYELOID NEOPLASIA Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome
Departments of 1Genetics and 2Pathology, and 3Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA; 4Departments of Pathology and Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, New York, NY; 5Department of Pediatrics, Stanford University, Stanford, CA; 6Department of Basic Medical Sciences, Purdue University, West Lafayette, IN; and 7Hudso...
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In this issue of the Revista Brasileira de Hematologia e Hemoterapia, Duarte et al.1 present data on the role of p53 protein expression and prognosis of patients with low-risk myelodysplastic syndrome (MDS). In a cohort of 38 patients, the authors demonstrated an association between mutant p53 protein expression and shortened survival. MDS is a clinically heterogeneous disorder.2 Patients with ...
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BACKGROUND At the time of diagnosis, more than 50% of patients with myelodysplastic syndrome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, current diagnostic tools lack the ability to look at genetic factors beyond karyotyping in order to determine the cause of this variability. OBJE...
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ژورنال
عنوان ژورنال: Blood
سال: 2011
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2010-11-318584